Antiproliferative Effects of Phytoestrogens Formononetin and Resveratrol Against Human Pulmonary Adenocarcinoma Cells A 549

Phytoestrogens are phytoalexins, plant secondary metabolites produced in response to microbial attacks and other forms of external stress stimuli. These compounds devoid the steroidal structure endogenous estrogens but could bind with estrogen receptors great affinity as they have structural similarity endogenous/synthetic estrogens. reported possess several health benefits including cardio protective, antidiabetic, antioxidant anti osteoporotic properties. like genistein, daidzein, equol been excellent proliferative anticancer Formononetin, is a phytoestrogen, isoflavone widely present red clover (Trifolium pratense) resveratrol phytoestrogen which grapes (Vitis vinifera). The protective property wine has attributed presence resveratrol. Although formononetin investigated extensively for pharmacological properties, reports on their effects especially against human pulmonary carcinoma cell lines very less. Hence current study aims understand influence these two growth adenocarcinoma line A 549. MTT assay, cytomorphology analysis by phase contrast microscopy, DNA topology assay DPPH were few assays performed antiproliferative compounds. Results indicated potent implicating that be potential therapeutic molecules multifaceted roles agents, antioxidants inflammatory agents.